In TWD. Amputation -- does it work? or not?
In the TV series it worked on Hershel. But in Telltale game it's not clear, it didn't work on Lee, but it worked on Reggie.idk if it worked on Sarita.
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To answer your question, it can work, but it's a risky proposition. Blood loss, shock and infection from unsterile equipment can kill just as surely as a bite.
It'll probably be the same case with Sarita as it was with Hershel - it might save her from the bite, but she'll most likely die from blood loss or other infection at the end of the day because Carlos is dead and we no longer have a doctor.
The only reason Hershel didn't die is because they had supplies to stop the bleeding. In Sarita's case they don't.
You do either of those things poorly, and the guy's dead. I think there was a guy in the comics who's arm was cut not more than 10 seconds after the bite, and he still died. Probably poor post-bite medical care. So doing the cutting fast alone isn't good enough.
The other issue is blood loss. As seen in the comics and game, you can die from the amputation itself instead of the bite. If done with good materials and a competent doctor, the amputation carries lower (but still considerable) risk. The doctor can tie off or cauterize arteries to minimize blood loss. But if you're dealing with inexperienced people or minimal equipment, it is highly likely a victim would die of blood loss.
Lastly, the materials you use to remove the infected area and clean up afterwards must be clean. Any unsanitary material can lead to a regular infection that can kill a patient (we're not talking about zombie infection here, just regular infections you see in today's world). Recent issues of the comics have confirmed that injuring a person with a weapon coated in walker 'gunk' will infect the victim and turn them into a walker. Thus, performing an amputation with a weapon used on walkers carries an extremely high risk of killing the victim.
So in summation, amputation can save a patient's life if done by a competent individual, done quickly, and it removes all parts of the body that have the walker's infection. Compromising any of these areas increases the risk to the victim.