What was your ending in BioShock 1, first time you played it?
What did you do to the Little Sisters in your first playthrough?
Save them or harvest their ADAM and murder them in the process?
I saved them. I don't have what it takes in me to murder a little girl. And I got some sweet ass gifts from Tenenbaum because of that, so it was well worth it 
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I got the bad ending because Atlas was my favorite
Saved them, which actually gives you more rewards anyway and gives you a better ending.
I saved them, they were totally safe in the back of my van
Yeah, it does.
Saved them. And will continue to save them in future playthroughs.
Same