No. He's just sleep deprived. Whilst the thought was definetly in my head when Clem went into the comic shop the second time, his health hasn't deteriorated enough in that time. Once he's able to "rest" (after been captured) he sounds and looks a lot healthier.
Nah, Luke hasn't been bitten. He's sleep deprived worrying about how to get his group out alive without being spotted. You also have to remember Luke has most likely been traveling on foot unlike Carver who had a truck..
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Lack of sleep can do many things to you.